endorphin

noun

en·​dor·​phin en-ˈdȯr-fən 

: any of a group of endogenous peptides (such as enkephalin) found especially in the brain that bind chiefly to opiate receptors and produce some pharmacological effects (such as pain relief) like those of opiates

specifically : beta-endorphin

Did you know?

The word endorphin was coined, back when the substances were discovered in the 1970s, by joining pieces of endogenous and morphine, morphine being a narcotic that closely resembles the endorphins and relieves pain in a similar way. Studies suggest that the pain-relieving practice called acupuncture works by releasing endorphins. Endorphins also seem to play an important role in pregnancy. Though much remains to be learned about the endorphins, the general public seems ready to give them credit for any all-natural high.

Examples of endorphin in a Sentence

Recent Examples on the Web

One such study found that this contrast therapy can improve circulation, boost endorphin levels and enhance overall well-being. —Bridget Fogarty, jsonline.com, 2 Feb. 2026

Movement releases endorphins, lowers stress hormones and provides a sense of accomplishment. —Fred Sassani, Austin American Statesman, 29 Jan. 2026

Regular physical activity, about 150 minutes of moderate exercise weekly, helps manage weight, reduce heart disease risk, and lift mood through endorphin release. —Care Resource, Miami Herald, 20 Jan. 2026

Beyond that, research finds that helping others can reduce stress, increase mood-boosting endorphins and contribute to better self-esteem. —Helen Carefoot, Flow Space, 1 Jan. 2026

Word History

Etymology

International Scientific Vocabulary endogenous + morphine

First Known Use

1976, in the meaning defined above

Phrases Containing endorphin

• beta-endorphin

Rhymes for endorphin

• dextromethorphan
• orphan

Medical Definition

endorphin

noun

en·​dor·​phin en-ˈdȯr-fən 

: any of a group of endogenous peptides (as enkephalin and dynorphin) found especially in the brain that bind chiefly to opiate receptors and produce some of the same pharmacological effects (as pain relief) as those of opiates

specifically : beta-endorphin