dystrophin

noun

dys·​tro·​phin ˈdi-strə-ˌfin How to pronounce dystrophin (audio)
: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy

Examples of dystrophin in a Sentence

Recent Examples on the Web But inspired by an older man who was missing nearly half of the protein yet had only mild muscular dystrophy, Chamberlain’s lab 2 decades ago devised a gene for a miniature dystrophin. Byjocelyn Kaiser, science.org, 23 May 2023 Duchenne is a rare fatal neuromuscular disease caused by mutations in the dystrophin gene that result in a progressive loss of muscle function and weakness, including in the heart and skeleton. BostonGlobe.com, 24 Dec. 2019 The guide RNAs were designed to trigger production of a missing protein called dystrophin. Sara Reardon, Scientific American, 5 Feb. 2020 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. BostonGlobe.com, 17 Dec. 2019 In a clinical trial, Vyondys 53 produced a small increase in an important muscle protein called dystrophin that children with Duchenne lack. BostonGlobe.com, 24 Dec. 2019 In a clinical trial, Sarepta’s drug produced a small increase in an important muscle protein called dystrophin that is normally missing in children with Duchenne. Damian Garde, STAT, 12 Dec. 2019 Instead, the Wave drug made no dystrophin protein at all, which raises serious questions about the viability of the company’s entire chemistry platform. BostonGlobe.com, 17 Dec. 2019

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'dystrophin.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

dystrophy + -in entry 1

Note: Term introduced by Eric P. Hoffman, Robert H. Brown, Jr., and Louis M. Kunkel in "Dystrophin: The protein product of the Duchenne muscular dystrophy locus," Cell, vol. 51, no. 6, December 24, 1987, pp. 919-28.

First Known Use

1987, in the meaning defined above

Time Traveler
The first known use of dystrophin was in 1987

Dictionary Entries Near dystrophin

dystrophic

dystrophin

dystrophy

Cite this Entry

“Dystrophin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/dystrophin. Accessed 22 Jul. 2024.

Medical Definition

dystrophin

noun
dys·​tro·​phin ˈdis-trə-ˌfin How to pronounce dystrophin (audio)
: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy

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