dystrophin

noun
dys·​tro·​phin | \ ˈdi-strə-ˌfin How to pronounce dystrophin (audio) \

Definition of dystrophin

: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy

Examples of dystrophin in a Sentence

Recent Examples on the Web

His research focuses on repairing dystrophin, the main protein missing in people with Duchenne. Orla Mccaffrey, Dallas News, "Boston research company bets on UT Southwestern researcher's gene therapy," 18 June 2019 The cells repaired the cut, enabling dystrophin production to be restored to levels that ranged from 3% to 90% of normal, depending on the muscle. Amy Dockser Marcus, WSJ, "Crispr Used to Repair Gene Mutation in Dogs With Muscular Dystrophy," 30 Aug. 2018 In the Science study, scientists programmed the Crispr system to cut the dogs’ DNA at a precise spot on the dystrophin gene. Amy Dockser Marcus, WSJ, "Crispr Used to Repair Gene Mutation in Dogs With Muscular Dystrophy," 30 Aug. 2018 The hallmark of Duchenne is the absence of dystrophin, a protein in skeletal muscle. The Editorial Board, WSJ, "A Risky Drug Approval Lesson," 4 July 2018 Reviewers complained that the drug didn’t produce enough dystrophin, and that the company’s clinical trial was too small, among other objections. The Editorial Board, WSJ, "A Risky Drug Approval Lesson," 4 July 2018 Hundreds or thousands of amino acids are linked together to form proteins such as insulin, collagen, dystrophin, myosin, and the thousands of others needed for life. Sharon Begley, STAT, "Genome ‘writers’ set their first goal: recoding human cells to resist viruses," 1 May 2018 This rare, genetic muscle-wasting disease leaves many of its victims dead by their 20s as patients don't produce enough of a critical protein, called dystrophin, which helps keep muscles intact. Fortune, "Brainstorm Health: Sarepta Stock Spikes, Zika for Brain Cancer, Lasker Prize Winners," 6 Sep. 2017 This resulted in a small bump in dystrophin production. Sy Mukherjee, Fortune, "This Controversial Biotech May Yet Defy Its Skeptics," 6 Sep. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'dystrophin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

See More

First Known Use of dystrophin

1987, in the meaning defined above

History and Etymology for dystrophin

dystrophy + -in entry 1

Note: Term introduced by Eric P. Hoffman, Robert H. Brown, Jr., and Louis M. Kunkel in "Dystrophin: The protein product of the Duchenne muscular dystrophy locus," Cell, vol. 51, no. 6, December 24, 1987, pp. 919-28.

Keep scrolling for more

Learn More about dystrophin

Statistics for dystrophin

Last Updated

17 Sep 2019

Look-up Popularity

Time Traveler for dystrophin

The first known use of dystrophin was in 1987

See more words from the same year

Keep scrolling for more

More Definitions for dystrophin

dystrophin

noun
dys·​tro·​phin | \ ˈdis-trə-ˌfin How to pronounce dystrophin (audio) \

Medical Definition of dystrophin

: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy

More from Merriam-Webster on dystrophin

Britannica.com: Encyclopedia article about dystrophin

Comments on dystrophin

What made you want to look up dystrophin? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

authorized for issue (as a bond)

Get Word of the Day daily email!

Test Your Vocabulary

Musical Words Quiz

  • gramophone
  • Which word describes a musical performance marked by the absence of instrumental accompaniment?
True or False

Test your knowledge - and maybe learn something along the way.

TAKE THE QUIZ
SCRABBLE® Sprint

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!