dystrophin

noun

dys·tro·phin | \ ˈdi-strə-ˌfin

Definition of dystrophin

: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy

Examples of dystrophin in a Sentence

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His research focuses on repairing dystrophin, the main protein missing in people with Duchenne. — Orla Mccaffrey, Dallas News, "Boston research company bets on UT Southwestern researcher's gene therapy," 18 June 2019 The cells repaired the cut, enabling dystrophin production to be restored to levels that ranged from 3% to 90% of normal, depending on the muscle. — Amy Dockser Marcus, WSJ, "Crispr Used to Repair Gene Mutation in Dogs With Muscular Dystrophy," 30 Aug. 2018 In the Science study, scientists programmed the Crispr system to cut the dogs’ DNA at a precise spot on the dystrophin gene. — Amy Dockser Marcus, WSJ, "Crispr Used to Repair Gene Mutation in Dogs With Muscular Dystrophy," 30 Aug. 2018 The hallmark of Duchenne is the absence of dystrophin, a protein in skeletal muscle. — The Editorial Board, WSJ, "A Risky Drug Approval Lesson," 4 July 2018 Reviewers complained that the drug didn’t produce enough dystrophin, and that the company’s clinical trial was too small, among other objections. — The Editorial Board, WSJ, "A Risky Drug Approval Lesson," 4 July 2018 Hundreds or thousands of amino acids are linked together to form proteins such as insulin, collagen, dystrophin, myosin, and the thousands of others needed for life. — Sharon Begley, STAT, "Genome ‘writers’ set their first goal: recoding human cells to resist viruses," 1 May 2018 This rare, genetic muscle-wasting disease leaves many of its victims dead by their 20s as patients don't produce enough of a critical protein, called dystrophin, which helps keep muscles intact. — Fortune, "Brainstorm Health: Sarepta Stock Spikes, Zika for Brain Cancer, Lasker Prize Winners," 6 Sep. 2017 This resulted in a small bump in dystrophin production. — Sy Mukherjee, Fortune, "This Controversial Biotech May Yet Defy Its Skeptics," 6 Sep. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'dystrophin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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25 Jun 2019

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The first known use of dystrophin was in 1987

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dystrophin

noun

dys·tro·phin | \ ˈdis-trə-ˌfin

Medical Definition of dystrophin

: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy