dystrophin

noun
dys·​tro·​phin | \ ˈdi-strə-ˌfin How to pronounce dystrophin (audio) \

Definition of dystrophin

: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy

Examples of dystrophin in a Sentence

Recent Examples on the Web In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. BostonGlobe.com, 17 Dec. 2019 Duchenne is a rare fatal neuromuscular disease caused by mutations in the dystrophin gene that result in a progressive loss of muscle function and weakness, including in the heart and skeleton. BostonGlobe.com, 24 Dec. 2019 The guide RNAs were designed to trigger production of a missing protein called dystrophin. Sara Reardon, Scientific American, 5 Feb. 2020 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. BostonGlobe.com, 17 Dec. 2019 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. Adam Feuerstein, STAT, 16 Dec. 2019 In a clinical trial, Vyondys 53 produced a small increase in an important muscle protein called dystrophin that children with Duchenne lack. BostonGlobe.com, 24 Dec. 2019 In a clinical trial, Sarepta’s drug produced a small increase in an important muscle protein called dystrophin that is normally missing in children with Duchenne. Damian Garde, STAT, 12 Dec. 2019 Instead, the Wave drug made no dystrophin protein at all, which raises serious questions about the viability of the company’s entire chemistry platform. BostonGlobe.com, 17 Dec. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'dystrophin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of dystrophin

1987, in the meaning defined above

History and Etymology for dystrophin

dystrophy + -in entry 1

Note: Term introduced by Eric P. Hoffman, Robert H. Brown, Jr., and Louis M. Kunkel in "Dystrophin: The protein product of the Duchenne muscular dystrophy locus," Cell, vol. 51, no. 6, December 24, 1987, pp. 919-28.

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The first known use of dystrophin was in 1987

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Cite this Entry

“Dystrophin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/dystrophin. Accessed 28 Sep. 2021.

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More Definitions for dystrophin

dystrophin

noun
dys·​tro·​phin | \ ˈdis-trə-ˌfin How to pronounce dystrophin (audio) \

Medical Definition of dystrophin

: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy

More from Merriam-Webster on dystrophin

Britannica.com: Encyclopedia article about dystrophin

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