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dys·tro·phin | \ ˈdi-strə-ˌfin 
\
\Definition of dystrophin
: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy
Examples of dystrophin in a Sentence
Recent Examples on the Web In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said.
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BostonGlobe.com, "Wave Life Sciences stock tumbles after failed Duchenne study - The Boston Globe," 17 Dec. 2019 Duchenne is a rare fatal neuromuscular disease caused by mutations in the dystrophin gene that result in a progressive loss of muscle function and weakness, including in the heart and skeleton.
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BostonGlobe.com, "Under its gene therapy licensing deal with Roche, Sarepta is eligible to receive up to $1.7 billion, in addition to the $1.1 billion, if the experimental treatment meets certain regulatory and sales goals, plus royalties on sales.," 24 Dec. 2019 The guide RNAs were designed to trigger production of a missing protein called dystrophin.
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Sara Reardon, Scientific American, "Step Aside, CRISPR: RNA Editing Is Taking Off," 5 Feb. 2020 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said.
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BostonGlobe.com, "Wave Life Sciences stock tumbles after failed Duchenne study - The Boston Globe," 17 Dec. 2019 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said.
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Adam Feuerstein, STAT, "Wave Life Sciences crashes on negative outcome of Duchenne muscular dystrophy study," 16 Dec. 2019 In a clinical trial, Vyondys 53 produced a small increase in an important muscle protein called dystrophin that children with Duchenne lack.
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BostonGlobe.com, "Under its gene therapy licensing deal with Roche, Sarepta is eligible to receive up to $1.7 billion, in addition to the $1.1 billion, if the experimental treatment meets certain regulatory and sales goals, plus royalties on sales.," 24 Dec. 2019 In a clinical trial, Sarepta’s drug produced a small increase in an important muscle protein called dystrophin that is normally missing in children with Duchenne.
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Damian Garde, STAT, "FDA changes course on Sarepta’s once-rejected muscular dystrophy drug," 12 Dec. 2019 Instead, the Wave drug made no dystrophin protein at all, which raises serious questions about the viability of the company’s entire chemistry platform.
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BostonGlobe.com, "Wave Life Sciences stock tumbles after failed Duchenne study - The Boston Globe," 17 Dec. 2019
See MoreThese example sentences are selected automatically from various online news sources to reflect current usage of the word 'dystrophin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
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More Definitions for dystrophin
dystrophin
noundys·tro·phin | \ ˈdis-trə-ˌfin \
\Medical Definition of dystrophin
: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy
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The first known use of dystrophin was in 1987
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