deaminase

noun
de·​am·​i·​nase | \ (ˌ)dē-ˈa-mi-ˌnās How to pronounce deaminase (audio) , -ˌnāz \

Definition of deaminase

: an enzyme that hydrolyzes amino compounds (such as amino acids) with removal of the amino group

Examples of deaminase in a Sentence

Recent Examples on the Web Splitting the enzyme, called a deaminase, into two harmless halves kept it from killing cells. Sharon Begley, STAT, "Gene-editing discovery could point the way toward a ‘holy grail’: cures for mitochondrial diseases," 8 July 2020 Crucially, the mutations that had broken these genes could in principle be fixed with an adenine deaminase that worked on DNA. The Economist, "BiotechnologyGene editing takes another step forward," 26 Oct. 2017 The enzyme needed is an adenine deaminase that works on DNA. The Economist, "BiotechnologyGene editing takes another step forward," 26 Oct. 2017 Ramus was born with adenosine deaminase deficiency (ADA), a condition also known as bubble boy disease that affects the immune system. Paul A. Smith, Milwaukee Journal Sentinel, "Smith: National hunt takes pulse of ruffed grouse, woodcock populations," 27 Oct. 2017 Creating this second base editor was harder than the first because an equivalent to the cytidine deaminase used by Dr Liu, which would be needed to pull it off, does not exist in nature. The Economist, "BiotechnologyGene editing takes another step forward," 26 Oct. 2017 Getting to the point of mutations Base editors borrow from CRISPR's components—guide RNAs (gRNAs) and Cas9 or other nucleases—but don't cut the double helix and instead chemically alter single bases with deaminase enzymes such as TadA and ADAR. Jon Cohen, Science | AAAS, "Novel CRISPR-derived 'base editors' surgically alter DNA or RNA, offering new ways to fix mutations," 25 Oct. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'deaminase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of deaminase

1920, in the meaning defined above

History and Etymology for deaminase

de- + amino + -ase

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Time Traveler for deaminase

Time Traveler

The first known use of deaminase was in 1920

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Statistics for deaminase

Cite this Entry

“Deaminase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/deaminase. Accessed 25 Jan. 2021.

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More Definitions for deaminase

deaminase

noun
de·​am·​i·​nase | \ (ˈ)dē-ˈam-ə-ˌnās, -ˌnāz How to pronounce deaminase (audio) \
variants: also desaminase \ (ˈ)des-​ How to pronounce deaminase (audio) \

Medical Definition of deaminase

: an enzyme that hydrolyzes amino compounds (as amino acids) with removal of the amino group

Comments on deaminase

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