Recent Examples of deaminase from the Web
Crucially, the mutations that had broken these genes could in principle be fixed with an adenine deaminase that worked on DNA.
The enzyme needed is an adenine deaminase that works on DNA.
Ramus was born with adenosine deaminase deficiency (ADA), a condition also known as bubble boy disease that affects the immune system.
Creating this second base editor was harder than the first because an equivalent to the cytidine deaminase used by Dr Liu, which would be needed to pull it off, does not exist in nature.
Getting to the point of mutations Base editors borrow from CRISPR's components—guide RNAs (gRNAs) and Cas9 or other nucleases—but don't cut the double helix and instead chemically alter single bases with deaminase enzymes such as TadA and ADAR.
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