cytokine

noun

cy·​to·​kine ˈsī-tə-ˌkīn How to pronounce cytokine (audio)
plural cytokines
: any of a class of immunoregulatory proteins (such as interleukin or interferon) that are secreted by cells especially of the immune system
Most cytokines are produced primarily in the presence of disease or immunization and contribute to immune responses, inflammation, and endothelial cell activation; others are involved in tissue repair.Charles A. Dinarello et al.
The proinflammatory cytokine interleukin-2 determines the magnitude and duration of the T-cell response immediately after antigen encounter and assists in the maturation of macrophages and the proliferation of B cells and natural killer cells …Chiea C. Khor et al.

Examples of cytokine in a Sentence

Recent Examples on the Web
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Previous studies have shown that physical exercise reduces bone loss in rats with periodontal disease, a chronic inflammation of tooth-adjacent tissues, and reduces inflammatory chemicals called cytokines in mice. New Atlas, 22 June 2025 Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety Cell. Jenny Lehmann, Discover Magazine, 9 Apr. 2025 Researchers found cannabinoids can inhibit the production of inflammatory cytokines and promote regulatory T cells, which are crucial for maintaining immune balance. Tribune Content Agency, Mercury News, 20 May 2025 Another fascinating finding was that the anti-inflammatory cytokine IL-10 seemed to reduce anxiety. Jenny Lehmann, Discover Magazine, 9 Apr. 2025 See All Example Sentences for cytokine

Word History

Etymology

cyt- + -kine (as in lymphokine)

First Known Use

1974, in the meaning defined above

Time Traveler
The first known use of cytokine was in 1974

Cite this Entry

“Cytokine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cytokine. Accessed 4 Jul. 2025.

Medical Definition

cytokine

noun
cy·​to·​kine ˈsīt-ə-ˌkīn How to pronounce cytokine (audio)
: any of a class of immunoregulatory proteins (as interleukin, tumor necrosis factor, and interferon) that are secreted by cells especially of the immune system

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