cross-re·​sis·​tance | \ ˌkrȯs-ri-ˈzi-stən(t)s How to pronounce cross-resistance (audio) \

Definition of cross-resistance

: tolerance (as of a bacterium) to a usually toxic substance (such as an antibiotic) that is acquired not as a result of direct exposure but by exposure to a related substance

First Known Use of cross-resistance

1946, in the meaning defined above

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The first known use of cross-resistance was in 1946

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Dictionary Entries Near cross-resistance

cross relation



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Cite this Entry

“Cross-resistance.” Dictionary, Merriam-Webster, Accessed 17 Oct. 2021.

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cross-re·​sis·​tance | \ ˌkrȯs-ri-ˈzis-tən(t)s How to pronounce cross-resistance (audio) \

Medical Definition of cross-resistance

: tolerance (as of a bacteria, malignant cell, or insect) to a usually toxic substance (as an antibiotic, chemotherapy drug, or pesticide) that is acquired not as a result of direct exposure but by exposure to a related substance The history of drug resistance in falciparum malaria suggests that these compounds may also enjoy only a short-lived glory and that cross-resistance with related compounds can be expected.— David J. Wyler, The Journal of the American Medical Association, 11 May 1984 … paclitaxel and docetaxel are being incorporated into adjuvant regimens on the basis of their antitumor activity in advanced breast cancer and the absence of cross-resistance with doxorubicin. — Charles L. Shapiro, et al., The New England Journal of Medicine, 28 June 2001


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