cor·​neo·​cyte | \ ˈkȯr-nē-ə-ˌsīt How to pronounce corneocyte (audio) \
plural corneocytes

Definition of corneocyte

: a terminally differentiated, anucleate, flattened, dead keratinocyte that is filled mostly with keratin filaments, has an insoluble envelope of cross-linked proteins, is connected to other corneocytes by desmosomes, and is embedded in a lipid bilayer matrix in the skin's stratum corneum … the structure of the stratum corneum is analogous to that of a brick wall, with corneocyte "bricks" held in place by the extracellular matrix "mortar" …— Peter M. Elias et al. Depending on their skin type, patients receive either a lotion or cream formulation for at-home use to help diminish corneocyte cohesion, prevent re-thickening of the stratum corneum, and stimulate collagen development.— Cheryl Guttman

Note: The process by which a keratinocyte is converted to a corneocyte is known as cornification.

First Known Use of corneocyte

1969, in the meaning defined above

History and Etymology for corneocyte

corne- (in stratum corneum) + -o- + -cyte

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The first known use of corneocyte was in 1969

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Cite this Entry

“Corneocyte.” Dictionary, Merriam-Webster, Accessed 17 Apr. 2021.

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