cor·​neo·​cyte ˈkȯr-nē-ə-ˌsīt How to pronounce corneocyte (audio)
plural corneocytes
: a terminally differentiated, anucleate, flattened, dead keratinocyte that is filled mostly with keratin filaments, has an insoluble envelope of cross-linked proteins, is connected to other corneocytes by desmosomes, and is embedded in a lipid bilayer matrix in the skin's stratum corneum
… the structure of the stratum corneum is analogous to that of a brick wall, with corneocyte "bricks" held in place by the extracellular matrix "mortar" …Peter M. Elias et al.
Depending on their skin type, patients receive either a lotion or cream formulation for at-home use to help diminish corneocyte cohesion, prevent re-thickening of the stratum corneum, and stimulate collagen development.Cheryl Guttman

Note: The process by which a keratinocyte is converted to a corneocyte is known as cornification.

Word History


corne- (in stratum corneum) + -o- + -cyte

First Known Use

1969, in the meaning defined above

Time Traveler
The first known use of corneocyte was in 1969

Dictionary Entries Near corneocyte

Cite this Entry

“Corneocyte.” Dictionary, Merriam-Webster, Accessed 28 Feb. 2024.

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