: a terminally differentiated, anucleate, flattened, dead keratinocyte that is filled mostly with keratin filaments, has an insoluble envelope of cross-linked proteins, is connected to other corneocytes by desmosomes, and is embedded in a lipid bilayer matrix in the skin's stratum corneum
… the structure of the stratum corneum is analogous to that of a brick wall, with corneocyte "bricks" held in place by the extracellular matrix "mortar" …—Peter M. Elias et al.
Depending on their skin type, patients receive either a lotion or cream formulation for at-home use to help diminish corneocyte cohesion, prevent re-thickening of the stratum corneum, and stimulate collagen development.—Cheryl Guttman
Note: The process by which a keratinocyte is converted to a corneocyte is known as cornification.
Love words? Need even more definitions?Merriam-Webster unabridged