Definition of cooperativity
: the quality or state of being cooperative To safeguard the scientific enterprise, cooperativity and humility need to instead become central virtues of science.— Natalie Koffler "It wasn't such a huge amount to achieve this cooperativity between these two different species" because wolves and humans shared similar social structures, [John] Allman argued.— Minerva Canto specifically, biochemistry : the molecular interaction between a ligand and a macromolecule (such as a protein) having two or more binding sites in which binding of a ligand to one site positively or negatively influences subsequent ligand binding at other sites by either increasing or decreasing the affinity of other binding sites for a ligand Cooperativity refers to the characteristic that the remaining hemoglobin chains will have greater affinity for O2 after one of the subunits has already bound O2. — Shannon Haymond et al. … a reduction in receptor affinity for its ligand with increasing saturation of binding sites (so-called 'negative cooperativity') has been described for a number of hormones … — Martin Raff
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