clo·​za·​pine ˈklō-zə-ˌpēn How to pronounce clozapine (audio)
: an antipsychotic drug C18H19ClN4 used in the treatment of schizophrenia

Examples of clozapine in a Sentence

Recent Examples on the Web Other countries have been more discerning about clozapine’s public health calculus, resulting in less-stringent monitoring regulations and more widespread clozapine prescribing. Brian Barnett, STAT, 9 May 2022 To prevent and rapidly address cases of agranulocytosis, the FDA requires clozapine’s manufacturers to jointly administer the clozapine REMS program. Brian Barnett, STAT, 9 May 2022 Frustratingly, the antipsychotic that works best against schizophrenia’s symptoms—clozapine, which emerged in the late 1980s—can have the nastiest unwanted effects, including weight gain, diabetes, and excessive sleepiness. WIRED, 10 Feb. 2023 For them, clozapine is the gold standard treatment. Brian Barnett, STAT, 9 May 2022 Many medications can cause excess salivation, such as clonozapam (Klonopin) and clozapine (Clozaril). Dr. Keith Roach, oregonlive, 7 Oct. 2021 He was evaluated by a doctor, now a defendant in the lawsuit, who did not prescribe clozapine. Sydney Czyzon, Milwaukee Journal Sentinel, 3 July 2019 Research suggests that chlorpromazine is the most likely to cause seizures among typical antipsychotics while clozapine is most likely among atypicals. Kimberly Truong, SELF, 7 Dec. 2018 Twenty days later, Mathew stopped regularly taking clozapine, an antipsychotic used to treat schizophrenia., 22 June 2019 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'clozapine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


International Scientific Vocabulary chlor- + -zapine, alteration of -azepine (as in benzodiazepine)

First Known Use

1970, in the meaning defined above

Time Traveler
The first known use of clozapine was in 1970

Dictionary Entries Near clozapine

Cite this Entry

“Clozapine.” Dictionary, Merriam-Webster, Accessed 2 Dec. 2023.

Medical Definition


clo·​za·​pine ˈklō-zə-ˌpēn How to pronounce clozapine (audio)
: an antipsychotic drug C18H19ClN4 with serious side effects (as seizures and agranulocytosis) that is used in the management of schizophrenia

Note: Clozapine is marketed under the trademark Clozaril.

More from Merriam-Webster on clozapine

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