antimetabolite

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noun an·ti·me·tab·o·lite \ˌan-tē-mə-ˈta-bə-ˌlīt, ˌan-ˌtī-\

Definition of antimetabolite

  1. :  a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metabolite's action From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids … — Mairin Brennan

antimetabolic

play \ˌan-tē-ˌme-tə-ˈbä-lik, ˌan-tī-\ adjective a drug with antimetabolic action

First Known Use of antimetabolite

1945


Medical Dictionary

antimetabolite

play
noun an·ti·me·tab·o·lite \ˌant-i-mə-ˈtab-ə-ˌlīt, ˌan-ˌtī-\

Medical Definition of antimetabolite

  1. :  a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.—Jane E. Brody, The New York Times, 15 May 1985 antimetabolite therapy

antimetabolic

\-ˌmet-ə-ˈbäl-ik\ play adjective In addition to its antimetabolic effects, methotrexate has immunological effects …—Robert S. Stern, The Lancet, 2 Aug. 1997

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