antimetabolite

noun an·ti·me·tab·o·lite \ ˌan-tē-mə-ˈta-bə-ˌlīt , ˌan-ˌtī- \

Definition of antimetabolite

:a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metaboliteʼs action
  • From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids …
  • —Mairin Brennan

antimetabolic

play \ˌan-tē-ˌme-tə-ˈbä-lik, ˌan-tī-\ adjective
    • a drug with antimetabolic action

First Known Use of antimetabolite

1945


Medical Dictionary

antimetabolite

noun an·ti·me·tab·o·lite \ ˌant-i-mə-ˈtab-ə-ˌlīt, ˌan-ˌtī- \

medical Definition of antimetabolite

:a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite
  • Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.
  • —Jane E. BrodyThe New York Times15 May 1985
  • antimetabolite therapy

antimetabolic

play \-ˌmet-ə-ˈbäl-ik\ adjective
    • In addition to its antimetabolic effects, methotrexate has immunological effects …
    • —Robert S. SternThe Lancet2 Aug. 1997

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