an·​ti·​me·​tab·​o·​lite | \ ˌan-tē-mə-ˈta-bə-ˌlīt , ˌan-ˌtī-\

Definition of antimetabolite

: a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metaboliteʼs action From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids …— Mairin Brennan

Other Words from antimetabolite

antimetabolic \ ˌan-​tē-​ˌme-​tə-​ˈbä-​lik , ˌan-​tī-​ \ adjective
a drug with antimetabolic action

First Known Use of antimetabolite

1945, in the meaning defined above

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The first known use of antimetabolite was in 1945

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an·​ti·​me·​tab·​o·​lite | \ ˌant-i-mə-ˈtab-ə-ˌlīt, ˌan-ˌtī- \

Medical Definition of antimetabolite

: a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.— Jane E. Brody, The New York Times, 15 May 1985 antimetabolite therapy

Other Words from antimetabolite

antimetabolic \ -​ˌmet-​ə-​ˈbäl-​ik \ adjective
In addition to its antimetabolic effects, methotrexate has immunological effects … — Robert S. Stern, The Lancet, 2 Aug. 1997

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a servile follower or underling

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