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Definition of antimetabolite
: a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metabolite's action From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids … — Mairin Brennan
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First Known Use of antimetabolite
1945
Medical Dictionary
antimetabolite
playMedical Definition of antimetabolite
: a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.—Jane E. Brody, The New York Times, 15 May 1985 antimetabolite therapy
antimetabolic
\-ˌmet-ə-ˈbäl-ik\ play adjective In addition to its antimetabolic effects, methotrexate has immunological effects …—Robert S. Stern, The Lancet, 2 Aug. 1997Learn More about antimetabolite
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Britannica.com: Encyclopedia article about antimetabolite
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