an·​ti·​his·​ta·​mine | \ ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio) , -mən, ˌan-tī- \

Definition of antihistamine

: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms

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Other Words from antihistamine

antihistamine adjective
antihistaminic \ ˌan-​tē-​ˌhi-​stə-​ˈmi-​nik How to pronounce antihistaminic (audio) , ˌan-​tī-​ \ adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web Records show chemical restraints used on Piney Ridge residents included antipsychotics Zyprexa or Thorazine given with the antihistamine Benadryl. Lisa Hammersly, Arkansas Online, "Child site violated U.S. rules, records show," 1 Dec. 2019 Over-the-counter: More plans are now offering credits for over-the-counter items such as antihistamines, appetite suppressants, toothbrushes, sunscreen and bandages. oregonlive, "Medicare 2020: Monthly premiums holding steady as open enrollment nears," 13 Oct. 2019 Toxicology tests detected a common antihistamine called diphenhydramine and THC, the active ingredient of marijuana, in his system. Fox News, "Oklahoma City police say shooting of naked and unarmed teen was justified," 9 Aug. 2019 In more severe cases, your doctor may prescribe oral corticosteroids or antihistamines, said Zeichner. Htv National Desk, Houston Chronicle, "Woman’s blistering 'margarita burn' a warning about the popular summer drink," 5 June 2019 If exposed, people with allergies should use a drug like injectable epinephrine, commonly sold as EpiPen, or for milder reactions, antihistamines. Nadia Kounang And Steve Almasy, CNN, "FDA takes major step toward approving first peanut allergy treatment," 13 Sep. 2019 Ten cases of minor allergy-like symptoms that include stuffy noses, sneezing and itchy, watery eyes have been reported, with a couple of people given congestive medication and antihistamines. Sig Christenson,, "San Antonio dorm project part of Air Force’s war on mold," 1 Aug. 2019 Ranitidine, as the drug is known in generic form, is an antacid and antihistamine used to treat and prevent a range of gastrointestinal disorders. Bloomberg News, oregonlive, "Zantac, generics may be tainted with cancer-causing agent, regulators say," 13 Sep. 2019 According to the Mayo Clinic, certain medications can screw with your body’s ability to stay hydrated, like diuretics, antihistamines, and antidepressants. Anna Borges, SELF, "How to Spot Heat Exhaustion Because, Wow, It's Freaking Hot Outside," 12 July 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antihistamine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of antihistamine

1933, in the meaning defined above

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Time Traveler for antihistamine

Time Traveler

The first known use of antihistamine was in 1933

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Statistics for antihistamine

Last Updated

5 Dec 2019

Cite this Entry

“Antihistamine.” The Dictionary, Merriam-Webster Inc., Accessed 7 December 2019.

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How to pronounce antihistamine (audio)

English Language Learners Definition of antihistamine

medical : a drug that is used to treat allergic reactions and colds


an·​ti·​his·​ta·​mine | \ ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio) \

Medical Definition of antihistamine

 (Entry 1 of 2)

: tending to block or counteract the physiological action of histamine human blood lacks antihistamine activity



Medical Definition of antihistamine (Entry 2 of 2)

: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

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