an·​ti·​his·​ta·​mine | \ ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio) , -mən, ˌan-tī- \

Definition of antihistamine

: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms

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Other Words from antihistamine

antihistamine adjective
antihistaminic \ ˌan-​tē-​ˌhi-​stə-​ˈmi-​nik How to pronounce antihistamine (audio) , ˌan-​tī-​ \ adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web All Day Allergy: available on AmazonGoodSense offers an antihistamine allergy medicine with 10mg of cetirizine hydrochloride to provide up to 24 hours of indoor and outdoor relief. Kevin Luna,, "Best over-the-counter allergy medicine," 1 Apr. 2021 Ordo had a form of Pyrilamine, an antihistamine, in his system. John Cherwa, Los Angeles Times, "Horse racing newsletter: Louis Rabaut’s Kentucky Oaks rankings are here," 5 Apr. 2021 The worker felt flush and took an antihistamine around 10 minutes after receiving the vaccine Tuesday afternoon, authorities said. Morgan Krakow Of Anchorage Daily News,, "Alaska health care worker hospitalized after receiving COVID-19 vaccine," 16 Dec. 2020 The woman starting feeling flushed about 10 minutes into that observation period, and took Benadryl, an antihistamine. NBC News, "Alaska health care worker had severe allergic reaction to Pfizer Covid-19 vaccine," 16 Dec. 2020 The worker felt flush and took an antihistamine around ten minutes after receiving the vaccine on Wednesday afternoon, authorities said. Morgan Krakow, Anchorage Daily News, "Alaska health care worker hospitalized after receiving COVID-19 vaccine," 16 Dec. 2020 Plus, all the participants were also taking an antihistamine. Elizabeth Gulino,, "Yes, Beyoncé Has 80,000 Bees. But Does Her Honey Have The Power To Heal?," 2 Nov. 2020 Other effective drugs identified in the research are cloperastine, a cough suppressant that has been around since the 1970s; clemastine, an antihistamine; and progesterone, a natural hormone that is also available as a medication. Peter Fimrite,, "UCSF-led researchers dig deep into coronavirus structure, identify drugs that could diminish COVID effects," 15 Oct. 2020 TikTok has moved to remove videos related to the challenge, which featured young people encouraging others to ingest high doses of the antihistamine to induce hallucinations, according to Healthline. Dalvin Brown, USA TODAY, "'Benadryl Challenge' on TikTok can cause 'serious problems,' the FDA warns," 25 Sep. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antihistamine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of antihistamine

1933, in the meaning defined above

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Time Traveler for antihistamine

Time Traveler

The first known use of antihistamine was in 1933

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Statistics for antihistamine

Last Updated

21 Apr 2021

Cite this Entry

“Antihistamine.” Dictionary, Merriam-Webster, Accessed 10 May. 2021.

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More Definitions for antihistamine



English Language Learners Definition of antihistamine

medical : a drug that is used to treat allergic reactions and colds


an·​ti·​his·​ta·​mine | \ ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio) \

Medical Definition of antihistamine

 (Entry 1 of 2)

: tending to block or counteract the physiological action of histamine human blood lacks antihistamine activity



Medical Definition of antihistamine (Entry 2 of 2)

: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

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