an·​ti·​his·​ta·​mine | \ ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio) , -mən, ˌan-tī- \

Definition of antihistamine

: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms

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Other Words from antihistamine

antihistamine adjective
antihistaminic \ ˌan-​tē-​ˌhi-​stə-​ˈmi-​nik How to pronounce antihistaminic (audio) , ˌan-​tī-​ \ adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web Other effective drugs identified in the research are cloperastine, a cough suppressant that has been around since the 1970s; clemastine, an antihistamine; and progesterone, a natural hormone that is also available as a medication. Peter Fimrite,, "UCSF-led researchers dig deep into coronavirus structure, identify drugs that could diminish COVID effects," 15 Oct. 2020 TikTok has moved to remove videos related to the challenge, which featured young people encouraging others to ingest high doses of the antihistamine to induce hallucinations, according to Healthline. Dalvin Brown, USA TODAY, "'Benadryl Challenge' on TikTok can cause 'serious problems,' the FDA warns," 25 Sep. 2020 Benadryl is an antihistamine used to treat symptoms such as a runny nose or sneezing from upper respiratory allergies, hay fever or the common cold. Shelby Lin Erdman, CNN, "FDA issues Benadryl warning as it investigates reports of teen injuries and deaths linked to TikTok challenge," 25 Sep. 2020 Benadryl contains diphenhydramine, an antihistamine that temporarily relieves symptoms caused by hay fever, upper respiratory allergies or the common cold, such as a runny nose and sneezing. Kate Gibson, CBS News, "TikTok "Benadryl Challenge" prompts FDA warning on overdoses," 25 Sep. 2020 Many of these adverse effects are due to the fact that diphenhydramine is not just an antihistamine, Dr. Stolbach explains. Sarah Jacoby, SELF, "Seriously, Do Not Take the TikTok ‘Benadryl Challenge’," 4 Sep. 2020 Four of the studies examined comparisons between honey and diphenhydramine, an antihistamine that can be used to relieve coughs, according to the U.S. government. Simone Jasper News & Observer, Star Tribune, "You may want to grab honey the next time you have a cold, study says," 27 Aug. 2020 Altamirano noted that people should feel reassured if their symptoms improve after taking an antihistamine like Zyrtec or Allegra. Priscilla Aguirre,, "Saharan dust is still in Texas. Here are the differences between allergies and the coronavirus.," 29 June 2020 While the treatment options for seasonal allergy symptoms vary, the first line of defense is usually an antihistamine, says Dr. Purcell. Maggie O'neill,, "The Seasonal Allergy Symptoms You Should Know About, According to an Allergist," 17 Apr. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antihistamine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of antihistamine

1933, in the meaning defined above

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Time Traveler for antihistamine

Time Traveler

The first known use of antihistamine was in 1933

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Statistics for antihistamine

Last Updated

29 Oct 2020

Cite this Entry

“Antihistamine.” Dictionary, Merriam-Webster, Accessed 30 Oct. 2020.

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More Definitions for antihistamine


How to pronounce antihistamine (audio)

English Language Learners Definition of antihistamine

medical : a drug that is used to treat allergic reactions and colds


an·​ti·​his·​ta·​mine | \ ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio) \

Medical Definition of antihistamine

 (Entry 1 of 2)

: tending to block or counteract the physiological action of histamine human blood lacks antihistamine activity



Medical Definition of antihistamine (Entry 2 of 2)

: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

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