an·​ti·​his·​ta·​mine | \ -ˈhis-tə-ˌmēn, -mən\

Definition of antihistamine

: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms

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Other Words from antihistamine

antihistamine adjective
antihistaminic \ -​ˌhis-​tə-​ˈmi-​nik \ adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web

This puffiness associated with allergies can be treated fairly easily with over-the-counter antihistamine meds, as well as nightly cold compresses to reduce swelling. Jenn Sinrich, SELF, "8 Reasons Your Eyes Look Tired That Have Nothing to Do With Sleep—and What You Can Do," 11 Sep. 2018 So can applying a hydrocortisone cream or calamine lotion (to ease inflammation and irritation) and taking an oral antihistamine (to combat your body’s release of histamine, the chemical involved in allergic reactions). Korin Miller, SELF, "7 Tips to Prevent Bee and Wasp Stings When Exploring the Great Outdoors," 10 Oct. 2018 Others are well-known allergens, such as nickel, medications like antihistamines, and airborne matter like pollen. Korin Miller, SELF, "Here’s Why Your Same Old Eye Makeup Is Suddenly Causing Irritation," 5 Oct. 2018 Treatment typically includes antihistamine and medications to lessen the itching. Matthew Diebel, USA TODAY, "Ee-ew! Authorities warn as sea lice invade beaches in Pensacola, northwest Florida," 27 June 2018 The hospital said those patients had received narcotic, antihistamine or sedative injections while the nurse was working. Fox News, "Hospital warns 2,600 ER patients to test for Hepatitis C," 1 May 2018 Bonjesta contains doxylamine succinate (an antihistamine found in over-the-counter sleep aids) and pyridoxine hydrochloride (the chemical name for a form of vitamin B6), which are the same active ingredients found in Diclegis. Korin Miller, SELF, "What to Know About Bonjesta, the Morning Sickness Drug Kim Kardashian Is Posting About on Instagram," 28 June 2018 There are conventional medications for morning sickness that are considered safe for pregnancy, such as vitamin B6 and doxylamine, an antihistamine sold under brands like Unisom. Michael Nedelman, CNN, "Cannabis dispensaries recommend products to pregnant women," 10 May 2018 If that doesn’t help, things like antihistamines and allergy shots might minimize your symptoms—talk to your doctor to figure out what makes the most sense. Korin Miller, SELF, "9 Health Issues That Can Cause Sensitivity to Light," 5 June 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antihistamine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of antihistamine

1933, in the meaning defined above

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Last Updated

3 Jan 2019

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Time Traveler for antihistamine

The first known use of antihistamine was in 1933

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More Definitions for antihistamine



English Language Learners Definition of antihistamine

medical : a drug that is used to treat allergic reactions and colds


an·​ti·​his·​ta·​mine | \ ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən \

Medical Definition of antihistamine

 (Entry 1 of 2)

: tending to block or counteract the physiological action of histamine human blood lacks antihistamine activity



Medical Definition of antihistamine (Entry 2 of 2)

: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

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