an·​ti·​his·​ta·​mine ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio)
: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms
antihistamine adjective
antihistaminic adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web But while some people are lucky enough not to need OTC meds after finishing their injections, others may still need to take antihistamines from time to time. Kathleen Felton, SELF, 10 June 2024 Our list includes products that contain natural ingredients, corticosteroids, and antihistamines, as well as items that use pressure or heat to relieve a bite. Laura Lu, Ms, Parents, 4 June 2024 Take oral antihistamines: Benadryl and other oral antihistamines can help alleviate itching and reduce allergic reactions. Tiffany Acosta, The Arizona Republic, 29 May 2024 If the itch is unbearable, pharmacists can provide prescription-strength anti-itch lotions or antihistamines. Divya Murthy, Detroit Free Press, 24 May 2024 See all Example Sentences for antihistamine 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'antihistamine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1946, in the meaning defined above

Time Traveler
The first known use of antihistamine was in 1946

Dictionary Entries Near antihistamine

Cite this Entry

“Antihistamine.” Dictionary, Merriam-Webster, Accessed 22 Jun. 2024.

Kids Definition


an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn How to pronounce antihistamine (audio)
: any of various drugs used for treating allergic reactions and cold symptoms

Medical Definition


1 of 2 adjective
an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio)
: tending to block or counteract the physiological action of histamine
human blood lacks antihistamine activity


2 of 2 noun
: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness
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