an·​ti·​his·​ta·​mine | \ ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio) , -mən, ˌan-tī- \

Definition of antihistamine

: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms

Other Words from antihistamine

antihistamine adjective
antihistaminic \ ˌan-​tē-​ˌhi-​stə-​ˈmi-​nik How to pronounce antihistamine (audio) , ˌan-​tī-​ \ adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web The first night, the hospital gave me a different antidepressant, and a type of antihistamine to treat my anxiety. Natasha Lavende, SELF, 13 Aug. 2021 Avoid scratching it, use anti-itch cream, take an antihistamine or apply a cold compress or ice to the site of the bite. Washington Post, 20 May 2021 All Day Allergy: available on AmazonGoodSense offers an antihistamine allergy medicine with 10mg of cetirizine hydrochloride to provide up to 24 hours of indoor and outdoor relief. Kevin Luna,, 1 Apr. 2021 Ordo had a form of Pyrilamine, an antihistamine, in his system. John Cherwa, Los Angeles Times, 5 Apr. 2021 The worker felt flush and took an antihistamine around 10 minutes after receiving the vaccine Tuesday afternoon, authorities said. Morgan Krakow Of Anchorage Daily News,, 16 Dec. 2020 The woman starting feeling flushed about 10 minutes into that observation period, and took Benadryl, an antihistamine. NBC News, 16 Dec. 2020 The worker felt flush and took an antihistamine around ten minutes after receiving the vaccine on Wednesday afternoon, authorities said. Morgan Krakow, Anchorage Daily News, 16 Dec. 2020 Plus, all the participants were also taking an antihistamine. Elizabeth Gulino,, 2 Nov. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antihistamine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of antihistamine

1933, in the meaning defined above

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Time Traveler for antihistamine

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The first known use of antihistamine was in 1933

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Cite this Entry

“Antihistamine.” Dictionary, Merriam-Webster, Accessed 26 Nov. 2021.

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More Definitions for antihistamine



English Language Learners Definition of antihistamine

: a drug that is used to treat allergic reactions and colds


an·​ti·​his·​ta·​mine | \ ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio) \

Medical Definition of antihistamine

 (Entry 1 of 2)

: tending to block or counteract the physiological action of histamine human blood lacks antihistamine activity



Medical Definition of antihistamine (Entry 2 of 2)

: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness


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