annealed; annealing; anneals
Definition of anneal
1a : to heat and then cool (a material, such as steel or glass) usually for softening and making less brittle Each bar, with its intricate twists, bevels and turns, had to be shaped individually. This shaping made some parts of the bars brittle … . To restore their flexibility, all the bars had to be annealed by heating, and then rapidly cooling them.— Ivars Peterson also : to cool slowly usually in a furnace
b : to cause two complementary strands of nucleic acid (such as DNA or RNA) to join by hydrogen bonding During repair of DNA double-strand breaks, cells must accurately anneal broken strands …— Seiji N. Sugiman-Marangos et al. also : to induce the binding of a genetic primer (see primer entry 2 sense 3) to a complementary single-stranded nucleic acid by slowly cooling single strands obtained from the heating and separation of double-stranded DNA or RNA The primers are annealed to the single strands when the local temperature is reduced to between 50 and 65 C. — Andrew J. DeMello During PCR, fragments are heated so they will separate into single strands. A short nucleotide sequence called a primer is then annealed to each original template. — George M. Church
1 : to pair with a complementary strand of nucleic acid A microRNA molecule can anneal to a messenger RNA (mRNA) containing a nucleotide sequence that complements the sequence of the microRNA …— Carlo M. Croce also : to bind to a complementary single-stranded nucleic acid during a process of heating and cooling Site-specific primers, designed to complement the base pairs of the DNA region flanking the target, anneal to these regions. — Norman Arnhelm and Corey H. Levenson
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