am·​pli·​con ˈam-plə-ˌkän How to pronounce amplicon (audio)
plural amplicons
: a segment of chromosomal DNA that undergoes amplification and contains replicated genetic material
After PCR, the amplicon is captured by hybridization to a specific oligonucleotide probe, which increases the overall specificity of the test.Benjamin T. Davis et al., New England Journal of Medicine, 19 Jan. 2006

Word History


ampli(fy) (in cloning-amplifying vector) + -icon (as in replicon)

First Known Use

1982, in the meaning defined above

Time Traveler
The first known use of amplicon was in 1982

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Dictionary Entries Near amplicon

Cite this Entry

“Amplicon.” Dictionary, Merriam-Webster, Accessed 29 Sep. 2023.

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