allostatic load


Definition of allostatic load

: the cumulative adverse effect on the body when allostasis occurs too frequently (as when the body is subjected to repeated stressors) or is inadequate Over weeks, months, or years, exposure to increased secretion of stress hormones can result in allostatic load and its pathophysiologic consequences.— Bruce S. McEwen, New England Journal of Medicine, 15 Jan. 1998

Love words?

You must — there are over 200,000 words in our free online dictionary, but you are looking for one that’s only in the Merriam-Webster Unabridged Dictionary.

Start your free trial today and get unlimited access to America's largest dictionary, with:

  • More than 250,000 words that aren't in our free dictionary
  • Expanded definitions, etymologies, and usage notes
  • Advanced search features
  • Ad free!

First Known Use of allostatic load

1996, in the meaning defined above

Keep scrolling for more

Learn More about allostatic load

Time Traveler for allostatic load

Time Traveler

The first known use of allostatic load was in 1996

See more words from the same year

Statistics for allostatic load

Cite this Entry

“Allostatic load.” Dictionary, Merriam-Webster, Accessed 27 Oct. 2020.

Comments on allostatic load

What made you want to look up allostatic load? Please tell us where you read or heard it (including the quote, if possible).


Test Your Vocabulary

Namesakes Word Quiz

  • a citrus fruit possibly named after a person
  • Which of the following is a fruit named after a Moroccan seaport?
Spell It

Can you spell these 10 commonly misspelled words?

Bee Cubed

Test Your Knowledge - and learn some interesting things along the way.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!