T cell receptor

noun
variants: or T-cell receptor
plural T cell receptors or T-cell receptors

Definition of T cell receptor

: an antigen receptor on the surface of a T cell that is composed of two transmembrane polypeptide chains covalently linked by disulfide bonds and that initiates T cell activation upon binding with a specific antigenic peptide fragment combined with a major histocompatibility complex molecule and displayed on the surface of an antigen-presenting cell … the T cell receptor actually recognizes not a solitary peptide but a complex consisting of a peptide and the surrounding region of the class I MHC molecule.— Thierry Boon … the T-cell receptor … acts as the antigen receptor for T cells one of whose principal functions is to recognize and destroy virus-infected cells …— Carl Branden et al. abbreviation TCR

First Known Use of T cell receptor

1972, in the meaning defined above

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The first known use of T cell receptor was in 1972

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Last Updated

27 Apr 2020

Cite this Entry

“T cell receptor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/T%20cell%20receptor. Accessed 27 May. 2020.

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More Definitions for T cell receptor

T cell receptor

noun
variants: or T-cell receptor

Medical Definition of T cell receptor

: an antigen receptor on the surface of a T cell that is composed of two transmembrane polypeptide chains covalently linked by disulfide bonds and that initiates T cell activation upon binding with a specific antigenic peptide fragment combined with a major histocompatibility complex molecule and displayed on the surface of an antigen-presenting cell … the T cell receptor actually recognizes not a solitary peptide but a complex consisting of a peptide and the surrounding region of the class I MHC molecule.— Thierry Boon … the T-cell receptor … acts as the antigen receptor for T cells one of whose principal functions is to recognize and destroy virus-infected cells …— Carl Branden et al. abbreviation TCR

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