plural STIs
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Examples of STI in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
In Broward County, a contract worth more than $2 million supported an STI testing and treatment center operated in partnership with the county health department. Zachary Bynum, CBS News, 13 Apr. 2026 Epstein also said that Gates had wanted to try to give that STI medication to French Gates in secret. Ava Berger, NPR, 8 Apr. 2026 Despite these advancements, STI rates in the United States continue to rise. Care Resource, Miami Herald, 6 Apr. 2026 Today, the organization provides low- to no-cost HIV/STI treatment and LGBTQ+ care at clinics across Central Illinois. Tess Kenny, Chicago Tribune, 5 Apr. 2026 Some centers also provide ultrasounds or STI testing. Emily Brindley health Reporter, Dallas Morning News, 27 Mar. 2026 The panel issues key recommendations on cancer screenings, STI testing, counseling and other preventive services. Alexandra Banner, CNN Money, 4 Mar. 2026 The vast majority focus on STI testing and treatment, contraceptive services, and cancer screenings. Fiorella Valdesolo, Allure, 3 Mar. 2026 Similarly, science is evolving for STI prevention options. Kenneth H. Mayer, STAT, 27 Feb. 2026

Word History

Etymology

sexually transmitted infection

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of STI was in 1983

Browse Nearby Words

Cite this Entry

“STI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/STI. Accessed 21 Apr. 2026.

Medical Definition

STI

abbreviation or noun
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster