plural STIs
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Examples of STI in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The panel issues key recommendations on cancer screenings, STI testing, counseling and other preventive services. Alexandra Banner, CNN Money, 4 Mar. 2026 The vast majority focus on STI testing and treatment, contraceptive services, and cancer screenings. Fiorella Valdesolo, Allure, 3 Mar. 2026 Similarly, science is evolving for STI prevention options. Kenneth H. Mayer, STAT, 27 Feb. 2026 In the show, The Beauty is an STI that transforms a person into someone physically perfect, but with deadly consequences. Barry Levitt, Time, 22 Jan. 2026 Experts told Flow Space that these approvals are major shots across the bow in the fight against increasing STI rates. Helen Carefoot, Flow Space, 30 Dec. 2025 The Mecklenburg County Public Health Department has also provided STI testing and education to 54 individuals — some unhoused, others not. Briah Lumpkins, Charlotte Observer, 5 Dec. 2025 The latter includes the 2014 Subaru Impreza WRX STI, one of the last cars driven by Paul Walker in the Fast & Furious movies. Lydia Mansel, Travel + Leisure, 30 Nov. 2025 Only one of the five public health nurses needed to fully staff the STI clinic remains with the health department, a spokesperson said. Sarah Volpenhein, jsonline.com, 13 Nov. 2025

Word History

Etymology

sexually transmitted infection

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of STI was in 1983

Browse Nearby Words

Cite this Entry

“STI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/STI. Accessed 11 Mar. 2026.

Medical Definition

STI

abbreviation or noun
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Last Updated: - Updated example sentences
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