\ ˈsərm How to pronounce SERM (audio) \

Definition of SERM

First Known Use of SERM

1994, in the meaning defined above

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The first known use of SERM was in 1994

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\ ˈsərm How to pronounce SERM (audio) \

Medical Definition of SERM

: selective estrogen receptor modulator Dramatic research findings have recently focused new attention on so-called designer estrogens, the medicines known more technically as selective estrogen receptor modulators (SERMs). These agents behave like estrogen in some tissues but block its action in others.— V. Craig Jordan, Scientific American, October 1998 The structural features of each SERM differ so that unique ligand-induced conformational changes take place in the ER [estrogen receptor], which are thought to be the likely basis for tissue-selective pharmacology. For example, raloxifene operates as an estrogen agonist in bone but as an antagonist in the breast and uterus.— Gideon A. Rodan et al., Science, 1 Sept. 2000

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