SERM

noun \ ˈsərm \

Definition of SERM

First Known Use of serm

1994


Medical Dictionary

SERM

noun \ ˈsərm \

medical Definition of SERM

:selective estrogen receptor modulator
  • Dramatic research findings have recently focused new attention on so-called designer estrogens, the medicines known more technically as selective estrogen receptor modulators (SERMs). These agents behave like estrogen in some tissues but block its action in others.
  • —V. Craig JordanScientific AmericanOctober 1998
  • The structural features of each SERM differ so that unique ligand-induced conformational changes take place in the ER [estrogen receptor], which are thought to be the likely basis for tissue-selective pharmacology. For example, raloxifene operates as an estrogen agonist in bone but as an antagonist in the breast and uterus.
  • —Gideon A. Rodan et al.Science1 Sept. 2000

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