First Known Use of serm
medical Definition of SERM
- Dramatic research findings have recently focused new attention on so-called designer estrogens, the medicines known more technically as selective estrogen receptor modulators (SERMs). These agents behave like estrogen in some tissues but block its action in others.
- —V. Craig Jordan, Scientific American, October 1998
- The structural features of each SERM differ so that unique ligand-induced conformational changes take place in the ER [estrogen receptor], which are thought to be the likely basis for tissue-selective pharmacology. For example, raloxifene operates as an estrogen agonist in bone but as an antagonist in the breast and uterus.
- —Gideon A. Rodan et al., Science, 1 Sept. 2000
Seen and Heard
What made you want to look up SERM? Please tell us where you read or heard it (including the quote, if possible).