: a semisynthetic illicit organic compound C20H25N3O derived from ergot that induces extreme sensory distortions, altered perceptions of reality, and intense emotional states, that may also produce delusions or paranoia, and that may sometimes cause panic reactions in response to the effects experienced

called also lysergic acid diethylamide

Examples of LSD in a Sentence

Recent Examples on the Web
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Experts say the directive could expedite studies on how psychedelic and hallucinatory drugs such as MDMA, psilocybin, LSD and ibogaine may be useful in medicine. Jackie Flynn Mogensen, Scientific American, 20 Apr. 2026 No psychedelic has been approved in the United States, but a number of them, including psilocybin, MDMA and LSD, are being studied in large trials for various mental health conditions. Matthew Perrone, Los Angeles Times, 19 Apr. 2026 No psychedelic has been approved in the United States, but a number of them are being studied in large trials for various mental health conditions, including psilocybin, MDMA and LSD. ABC News, 18 Apr. 2026 The Jefferson County Sheriff’s Office announced Thursday that the investigation started after an anonymous tip alleged that 25-year-old Hunter Covelli was selling large quantities of cocaine, MDMA, ketamine and LSD in Wheat Ridge. Jessica Alvarado Gamez, Denver Post, 17 Apr. 2026 See All Example Sentences for LSD

Word History

Etymology

borrowed from German, from Lysergsäure-Diäthylamid "lysergic acid diethylamide"

First Known Use

1950, in the meaning defined above

Time Traveler
The first known use of LSD was in 1950

Browse Nearby Words

Cite this Entry

“LSD.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/LSD. Accessed 22 Apr. 2026.

Kids Definition

: an illegal drug that causes abnormal sensations, extreme and changeable states of emotion, unnatural changes in the way time and space are experienced, and hallucinations and that may sometimes cause panic in response to the effects experienced

Medical Definition

: a semisynthetic illicit organic compound C20H25N3O derived from ergot that induces extreme sensory distortions, altered perceptions of reality, and intense emotional states, that may also produce delusions or paranoia, and that may sometimes cause panic reactions in response to the effects experienced

called also acid, lysergic acid diethylamide, lysergide

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