endorphin

noun

en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (such as enkephalin) found especially in the brain that bind chiefly to opiate receptors and produce some pharmacological effects (such as pain relief) like those of opiates
specifically : beta-endorphin

Did you know?

The word endorphin was coined, back when the substances were discovered in the 1970s, by joining pieces of endogenous and morphine, morphine being a narcotic that closely resembles the endorphins and relieves pain in a similar way. Studies suggest that the pain-relieving practice called acupuncture works by releasing endorphins. Endorphins also seem to play an important role in pregnancy. Though much remains to be learned about the endorphins, the general public seems ready to give them credit for any all-natural high.

Examples of endorphin in a Sentence

Recent Examples on the Web
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Singing is proven to release positive neurochemicals such as endorphin, dopamine, and serotonin, acting as a natural antidepressant. Hailey Roden, The Enquirer, 31 Aug. 2025 Hot, fresh bread with sweet butter creates a release of endorphins. Fort Worth Star-Telegram, 30 Aug. 2025 Though endorphins are just one of several types of protein molecules with this painkiller quality, the word is often used to refer to them collectively. Dr. Sanjay Gupta, CNN Money, 26 Aug. 2025 Recognizing a teammate’s effort can stimulate dopamine; expressing genuine gratitude can activate oxytocin; giving employees autonomy over their work can boost serotonin; and sharing a light-hearted moment or story can trigger endorphins and lift team morale. Anjali Chaudhry, Forbes.com, 24 Aug. 2025 See All Example Sentences for endorphin

Word History

Etymology

International Scientific Vocabulary endogenous + morphine

First Known Use

1976, in the meaning defined above

Time Traveler
The first known use of endorphin was in 1976

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Cite this Entry

“Endorphin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/endorphin. Accessed 10 Sep. 2025.

Medical Definition

endorphin

noun
en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (as enkephalin and dynorphin) found especially in the brain that bind chiefly to opiate receptors and produce some of the same pharmacological effects (as pain relief) as those of opiates
specifically : beta-endorphin

More from Merriam-Webster on endorphin

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