plural E. coli
: an enterobacterium (Escherichia coli) that is used in public health as an indicator of fecal pollution (as of water or food) and in medicine and genetics as a research organism and that occurs in various strains that may live as harmless inhabitants of the human lower intestine or may produce a toxin causing intestinal illness see enterobacterium illustration

Examples of E. coli in a Sentence

Recent Examples on the Web
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Over 40 bills in state legislatures seek to expand raw milk sales, even as a new E. coli outbreak tied to raw milk cheese sickens nine people, including children under age 5. Laura Ungar, Los Angeles Times, 3 May 2026 The researchers took 39 essential or highly expressed E. coli genes and replaced every isoleucine with valine or leucine, like a genetic find-and-replace. Jacek Krywko, Scientific American, 30 Apr. 2026 The current bout has sickened nine people with E. coli, half of them children under 5. Jim Edwards, Fortune, 30 Apr. 2026 Editing all 4,500 or so genes in E. coli would be a monumental task, and that many changes at once would almost certainly end up killing it, so the researchers started out with much smaller tests. ArsTechnica, 30 Apr. 2026 See All Example Sentences for E. coli

Word History

First Known Use

1925, in the meaning defined above

Time Traveler
The first known use of E. coli was in 1925

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Cite this Entry

“E. coli.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/E.%20coli. Accessed 9 May. 2026.

Kids Definition

E. coli

noun
plural E. coli
: a bacterium in the shape of a short rod that may cause intestinal illness
Etymology

short for Escherichia coli, the taxonomic name in biology

Medical Definition

E. coli

noun
ˌē-ˈkō-ˌlī
plural E. coli also E. colis
: a straight rod-shaped gram-negative bacterium (Escherichia coli of the family Enterobacteriaceae) that is used in public health as an indicator of fecal pollution (as of water or food) and in medicine and genetics as a research organism and that occurs in various strains that may live as harmless inhabitants of the human lower intestine or may produce a toxin causing intestinal illness marked especially by diarrhea
one million acid-resistant E. coli per gram of fecesJohn Schwartz
this E. coli can survive … longer than all the other E. colisEd Geldreich
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