COX-2 inhibitor

noun

\ ˈkäks-ˈtü-

Definition of COX-2 inhibitor

: any of a class of drugs used to treat the pain and inflammation of arthritis by selectively blocking the variant of cyclooxygenase causing these symptoms

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The first known use of COX-2 inhibitor was in 1994

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COX-2 inhibitor

noun

variants: also COX-2 blocker

Medical Definition of COX-2 inhibitor

: any of a class of drugs (as celecoxib) that are NSAIDs which selectively block the isoform COX-2 but not the isoform COX-1 of cyclooxygenase and are used chiefly to relieve the pain and inflammation of arthritis while minimizing gastrointestinal side effects COX-2 inhibitors, as their name implies, were designed to block just the inflammatory functions of the COX-2 enzyme, leaving the stomach-protecting functions of the COX-1 form intact. —Alice Park, Time, 28 Feb. 2005