Definition of COX–2 inhibitor
: any of a class of drugs used to treat the pain and inflammation of arthritis by selectively blocking the variant of cyclooxygenase causing these symptoms
First Known Use of cox–2 inhibitor
Medical Definition of COX–2 inhibitor
: any of a class of drugs (as celecoxib) that are NSAIDs which selectively block the isoform COX-2 but not the isoform COX-1 of cyclooxygenase and are used chiefly to relieve the pain and inflammation of arthritis while minimizing gastrointestinal side effects COX-2 inhibitors, as their name implies, were designed to block just the inflammatory functions of the COX-2 enzyme, leaving the stomach-protecting functions of the COX-1 form intact.—Alice Park, Time, 28 Feb. 2005
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