1
as in to begin
to take the first step in (a process or course of action)
I'll kick off the discussion on ethics with this question
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2
as in to die
slang
to stop living
surprisingly, the recluse was worth a cool million when he kicked off
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as in beginning
the point at which something begins
a political cycle in which an election marks not only the end of one campaign but also the kickoff for the next one
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Merriam-Webster unabridged
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