Medical Definition of neurofibrillary tangle
: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease
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Dictionary: Definition of "neurofibrillary tangle" Britannica.com: Encyclopedia article about "neurofibrillary tangle"
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