irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

Fortunately, there are ways to manage the dryness and irritation, including taking warm (not hot) baths, using a humidifier and applying a creamy, fragrance-free moisturizer within three minutes of bathing and throughout the day, the AADA notes. —Elizabeth Yuko, Flow Space, 7 July 2025

And despite the tight fit, the fabric felt soft against the skin without any abrasion or irritation. —Kevin Brouillard, Travel + Leisure, 3 July 2025

Harshly scrubbing the skin can lead to irritation that may contribute to accelerated visible aging in the form of wrinkles. —Cristina Mutchler, Verywell Health, 2 July 2025

Naseem reviewed those documents before shifting her irritation toward the DHS attorney, questioning why the error wasn't fixed. —Noe Padilla, IndyStar, 2 July 2025

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part