upstream

up·stream

adverb or adjective \ˈəp-ˈstrēm\

: in the direction opposite to the flow in a stream, river, etc. : toward the source of a stream, river, etc.

Full Definition of UPSTREAM

1

:  in the direction opposite to the flow of a stream

2

:  in or to a position within the production stream closer to manufacturing processes <make most of its money upstream, selling cheap crude … to refineries — John Quirt>

Yes, "irregardless" is a word. No, that
doesn't mean you should use it. »

First Known Use of UPSTREAM

1681

Rhymes with UPSTREAM

abeam, agleam, airstream, berseem, beseem, bireme, blaspheme, bloodstream, centime, coal seam, cold cream, crossbeam, daydream, downstream, dream team, drill team, egg cream, esteem, extreme, French seam, grapheme, Gulf Stream, hakim, headstream, high beam, hornbeam, I beam, ice cream, inseam, jet stream, kilim, lexeme, live steam, low beam, mainstream, midstream, millime, millstream, moonbeam, morpheme, onstream, phoneme, pipe dream, redeem, regime, rhyme scheme, sealed-beam, sememe, sidestream, slipstream, sour cream, sunbeam, supreme, tag team, Tarim, third-stream, toneme, trireme, unseam, warp beam, wet dream

up·stream

adverb or adjective \ˈəp-ˈstrēm\   (Medical Dictionary)

Medical Definition of UPSTREAM

: in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5′ in the terminal nucleotide <a small coding sequence is located just upstream from each…gene—J. N. Goldman et al>—compare downstream