Dictionary

upstream

adverb or adjective up·stream \ˈəp-ˈstrēm\

: in the direction opposite to the flow in a stream, river, etc. : toward the source of a stream, river, etc.

Full Definition of UPSTREAM

1
:  in the direction opposite to the flow of a stream
2
:  in or to a position within the production stream closer to manufacturing processes <make most of its money upstream, selling cheap crude … to refineries — John Quirt>

First Known Use of UPSTREAM

1681

upstream

adverb or adjective up·stream \ˈəp-ˈstrēm\   (Medical Dictionary)

Medical Definition of UPSTREAM

:  in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5′ in the terminal nucleotide <a small coding sequence is located just upstream from each…gene—J. N. Goldman et al>—compare downstream

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