Simple Definition of upstream
: in the direction opposite to the flow in a stream, river, etc. : toward the source of a stream, river, etc.
Full Definition of upstream
1 : in the direction opposite to the flow of a stream
2 : in or to a position within the production stream closer to manufacturing processes <make most of its money upstream, selling cheap crude … to refineries — John Quirt>
First Known Use of upstream
Rhymes with upstream
abeam, agleam, airstream, berseem, beseem, bireme, blaspheme, bloodstream, centime, coal seam, cold cream, crossbeam, daydream, downstream, dream team, drill team, egg cream, esteem, extreme, French seam, grapheme, Gulf Stream, hakim, headstream, high beam, hornbeam, I beam, ice cream, inseam, jet stream, kilim, lexeme, live steam, low beam, mainstream, midstream, millime, millstream, moonbeam, morpheme, onstream, phoneme, pipe dream, redeem, regime, rhyme scheme, sealed-beam, sememe, sidestream, slipstream, sour cream, sunbeam, supreme, tag team, Tarim, third-stream, toneme, trireme, unseam, warp beam, wet dream
UPSTREAM Defined for Kids
Definition of upstream for Students
: at or toward the beginning of a stream <She rowed upstream.>
Medical Definition of upstream
1: in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5′ in the terminal nucleotide <… stretches of DNA upstream of genes—are known as promoters.—Matt Ridley, Time, 2 June 2003>—compare downstream 1
2: toward the beginning of series of cellular processes : preceding a linked molecular event occurring in a sequence <It's equally important to focus on additional mechanisms that are upstream of amyloid formation and mechanisms downstream that are involved in the actual degenerative processes within neurons.—Marc Tessier-Lavigne, quoted in Science, 17 Sept. 2010>
Seen and Heard
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