Dictionary

downstream

adverb or adjective down·stream \ˈdan-ˈstrēm\

: in the direction in which a stream, river, etc., flows

Full Definition of DOWNSTREAM

1
:  in the direction of or nearer to the mouth of a stream
2
:  in or toward the latter stages of a usually industrial process or the stages (as marketing) after manufacture

First Known Use of DOWNSTREAM

1706

downstream

adverb or adjective down·stream \ˌdan-ˈstrēm\   (Medical Dictionary)

Medical Definition of DOWNSTREAM

:  in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide <a nucleotide sequence located downstream from the regulatory gene> <effects on the expression of downstream genes>—compare upstream

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