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The Adobe Flash Player is required in order to view this content. You can get it here: neurofibrillary tangleMain Entry: neurofibrillary tangle Function: noun Date: 1973 : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease 
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