I was overcome by despair at being unable to find them.
She finally gave up in despair.
The people were driven to despair by the horrors of war.
This latest setback has brought her to the depths of despair.
On the occasion of Johnson's tercentenary, Martin (A Life of James Boswell) searches out the psychological elements covered up by Boswell and others: the immense insecurities, bouts of deep depression, corrosive self-doubt and, in his last days, despair for his very soul. —Publishers Weekly, 21 July 2008
Players who'd been on the 2004 Olympic team joked about whether their two bronze medals equaled one silver. There was none of the despair or finger-pointing that followed the world championships in '02, when Team USA finished sixth. —Kelly Anderson, Sports Illustrated, 11 Sept. 2006
The people who try to save endangered species in Hawaii are immune to despair. They have to be, to keep doing what they do. —Lawrence Downes, New York Times, 19 Dec. 2004