aspartame

noun

as·​par·​tame ˈa-spər-ˌtām  ə-ˈspär-ˌtām 

: a crystalline compound C₁₄H₁₈N₂O₅ that is a diamide synthesized from phenylalanine and aspartic acid and that is used as a low-calorie sweetener

Examples of aspartame in a Sentence

Recent Examples on the Web

For the sweetener aspartame, the higher amount is equivalent to one can of diet soda. —Hannah Millington, MSNBC Newsweek, 3 Sep. 2025

Manufacturers artificially create sugar alcohols and use them as bulking sugars to cut the intense sweetness of other no-calorie sweeteners such as aspartame. —Sandee Lamotte, CNN Money, 3 Sep. 2025

Trump is a longtime fan of Diet Coke, which uses the artificial sweetener aspartame, and even has a button in the Oval Office to summon the drink. —Amelia Lucas, CNBC, 22 July 2025

Trump is a noted fan of Diet Coke, a product line that is mainly sweetened with the artificial sweetener aspartame. —Bill Chappell, NPR, 22 July 2025

Word History

Etymology

aspartic acid + phenylalanine + methyl + ester

First Known Use

1972, in the meaning defined above

Rhymes for aspartame

• counterclaim
• overcame
• underframe
• username
• acclaim
• aflame
• airframe
• ballgame
• became
• declaim
• defame
• disclaim

Medical Definition

aspartame

noun

as·​par·​tame ˈas-pər-ˌtām  ə-ˈspär- 

: a crystalline dipeptide ester C₁₄H₁₈N₂O₅ that is synthesized from the amino acids phenylalanine and aspartic acid and is used as a low-calorie sweetener see nutrasweet