an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Jenna Anderson, Health, 17 June 2026
In more than one letter, Diana makes rare comments to Stamp about the antidepressant Prozac.
—Rachel Burchfield, InStyle, 9 June 2026
Britt Hayes, Entertainment Weekly, 16 June 2026
Millions of women are walking into doctors’ offices with fatigue, anxiety and brain fog and walking out with a thyroid prescription or an antidepressant.
—Allison Palmer
updated June 13, Sacbee.com, 13 June 2026
See All Example Sentences for antidepressant
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Adjective
Nearly 375,000 bottles of the antidepressant duloxetine have been recalled, according to the Food and Drug Administration.
—Jenna Anderson, Health, 17 June 2026
In more than one letter, Diana makes rare comments to Stamp about the antidepressant Prozac.
—Rachel Burchfield, InStyle, 9 June 2026
Noun
According to the toxicology report, Thalassitis had alcohol, cocaine, and antidepressants in his system at the time of death.
—Britt Hayes, Entertainment Weekly, 16 June 2026
Millions of women are walking into doctors’ offices with fatigue, anxiety and brain fog and walking out with a thyroid prescription or an antidepressant.
—Allison Palmer
updated June 13, Sacbee.com, 13 June 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 23 Jun. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
