an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Sarah Rumpf-Whitten , Adam Sabes, FOXNews.com, 3 Feb. 2026
In general, it is estimated that about 1 in 6 people who discontinue their antidepressant experiences adverse symptoms.
—The New York Times News Service Syndicate, San Diego Union-Tribune, 27 Jan. 2026
Nicholas Florko, The Atlantic, 6 Feb. 2026
They might first be prescribed antidepressants instead of hormone replacement therapy.
—Laura Trujillo, USA Today, 3 Feb. 2026
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Adjective
Investigators found medications, including an antidepressant and antihistamine drugs, in Monique’s system at the time of her death.
—Sarah Rumpf-Whitten , Adam Sabes, FOXNews.com, 3 Feb. 2026
In general, it is estimated that about 1 in 6 people who discontinue their antidepressant experiences adverse symptoms.
—The New York Times News Service Syndicate, San Diego Union-Tribune, 27 Jan. 2026
Noun
The same is true for Pristiq, an antidepressant.
—Nicholas Florko, The Atlantic, 6 Feb. 2026
They might first be prescribed antidepressants instead of hormone replacement therapy.
—Laura Trujillo, USA Today, 3 Feb. 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 11 Feb. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
