1
as in suggestive
clearly conveying a special meaning (as one's mood)
after remarking that tardiness was on the rise, our boss cast a significant glance my way
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2
as in indicative
indicating something
the town's generous library budget is significant of the value its residents place on learning
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3
as in major
having great meaning or lasting effect
made a significant change in the procedure for applying for citizenship
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4
as in influential
having great power or influence
a producer who is playing a significant role in the creation of the new film
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5
as in considerable
sufficiently large in size, amount, or number to merit attention
paid a significant amount of money for the movie rights to the book
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significant differences
remarkable differences
drastic differences
tremendous differences
considerable differences
substantial differences
a significant increase
significant changes
a significant relationship
a meaningful relationship
an important relationship
a relevant relationship
a prominent relationship
a notable relationship
a significant role
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Merriam-Webster unabridged
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