estrangement

the loss of friendship or affection <a silly quarrel that eventually resulted in a complete and lasting estrangement between the onetime friends> Synonyms alienation, disaffection, disgruntlement, souring Related Words antagonism, embitterment, envenoming; breach, breakup, divorce, rift, rupture, schism, separation, split; animosity, antagonism, antipathy, bitterness, hostility, jaundice, rancor; aggravation, furor, fury, incensing, indignation, infuriation, ire, outrage, rage, spleen, wrath; disenchantment, disillusionment Near Antonyms endearment, ingratiation; appeasement, conciliation, mollification, pacification, propitiation Antonyms reconcilement, reconciliation