substance

sub·stance

noun \ˈsəb-stən(t)s\

Definition of SUBSTANCE

1

: physical material from which something is made or which has discrete existence <the substance of nerve tissue>

2

: matter of particular or definite chemical constitution

3

: something (as alcohol, methamphetamine, or marijuana) deemed harmful and usually subject to legal restriction <heroin is a controlled substance> <substance abuse>