Main Entry: re·frac·to·ry

Pronunciation: \ri-ˈfrak-t(ə-)rē\

Function: adjective

1 : resistant to treatment or cure <a refractory fulminant lesion> <had disease that was extremely refractory to multiple intensive therapies—Michelle L. Bennett et al>
2 : unresponsive to stimulus <the refractory period of a muscle fiber>
3 : resistant or not responding to an infectious agent : immune <refractory to reinfection>