refractory

re·frac·to·ry

adj \ri-ˈfrak-t(ə-)rē\

Definition of REFRACTORY

1

: resistant to treatment or cure <a refractory fulminant lesion> <had disease that was extremely refractory to multiple intensive therapies—Michelle L. Bennett et al>

2

: unresponsive to stimulus <the refractory period of a muscle fiber>

3

: resistant or not responding to an infectious agent : immune <refractory to reinfection>