Medical Definition of prion disease
: any of a group of spongiform encephalopathies that are caused and transmitted by prions and that include bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker syndrome, kuru, scrapie, and variant Creutzfeldt-Jakob disease—called also transmissible spongiform encephalopathy
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