Medical Definition of knot
1: an interlacing of the parts of one or more flexible bodies (as threads or sutures) in a lump to prevent their spontaneous separation—see surgeon's knot
2: a usually firm or hard lump, swelling, or protuberance (as in a muscle or on the surface of a bone) or process <a knot in a gland> <a bone with two or three knots>
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