Down syndrome
noun
variants
or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21
called also trisomy 21
Examples of Down syndrome in a Sentence
Recent Examples on the Web
One of the brothers has Down syndrome, and the other brother becomes his caregiver as his closest remaining family member.
—
Andrew McGowan, Variety, 8 Sep. 2025
Moreover, Nationwide Children’s Hospital, reports that life expectancy for people with Down syndrome has risen from around 25 years in 1983 to 60 years or more in countries with strong health systems.
—Dianne Plummer, Forbes.com, 2 Sep. 2025
Brown said Dutton Farm started as a family affair in 2010 to help her sister, Becca Smither, who was born with Down syndrome.
—Carol Cain, Freep.com, 1 Sep. 2025
Shortly after giving birth, the family learned that Jones was born with Down syndrome as well as a rare congenital colon abnormality that required surgery and a month-long stay in the hospital's neonatal intensive care unit (NICU).
—Caroline Blair, People.com, 28 Aug. 2025
See All Example Sentences for Down syndrome
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Andrew McGowan, Variety, 8 Sep. 2025
Moreover, Nationwide Children’s Hospital, reports that life expectancy for people with Down syndrome has risen from around 25 years in 1983 to 60 years or more in countries with strong health systems.
—Dianne Plummer, Forbes.com, 2 Sep. 2025
Brown said Dutton Farm started as a family affair in 2010 to help her sister, Becca Smither, who was born with Down syndrome.
—Carol Cain, Freep.com, 1 Sep. 2025
Shortly after giving birth, the family learned that Jones was born with Down syndrome as well as a rare congenital colon abnormality that required surgery and a month-long stay in the hospital's neonatal intensive care unit (NICU).
—Caroline Blair, People.com, 28 Aug. 2025
See All Example Sentences for Down syndrome
Cite this Entry
“Down syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Down%20syndrome. Accessed 18 Sep. 2025.
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