Main Entry: Schultz–Dale reaction

Pronunciation: \ˈshu̇ltz-ˈdāl-\

Function: noun

: a reaction of anaphylaxis carried out in vitro with isolated tissues

Schultz, Werner (1878–1947), German internist. Schultz is best known for his classic description of agranulocytosis in 1922. He did his research on anaphylaxis independently of Dale and carried out his in vitro testing using the intestinal muscles of guinea pigs.

Dale, Sir Henry Hallet (1875–1968), British physiologist and pharmacologist. Dale was one of the outstanding physiologists and pharmacologists of the first half of the 20th century. His early research work centered on the physiological actions of ergot. His work with isolated guinea pig uteri established that the anaphylactic antibodies are attached to cells. He reported on the results of his research on anaphylaxis in 1919. For their discoveries in the chemical transmission of nerve impulses, he and the German pharmacologist Otto Loewi were awarded the Nobel Prize for Physiology or Medicine in 1936.