Medical Definition of anneal
1: to heat and then cool (as steel or glass) usually for softening and making less brittle
2: to heat and then cool (double-stranded nucleic acid) in order to separate strands and induce combination at lower temperatures especially with complementary strands
: to be capable of combining with complementary nucleic acid by a process of heating and cooling <some bacterial nucleic acid anneals well with eukaryotic DNA>
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