androgen insensitivity syndrome
Medical Definition of androgen insensitivity syndrome
: a genetic disorder that causes complete or partial insensitivity to androgens in the body ◆A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring. <If a chromosomally male embryo has androgen-insensitivity syndrome, … the cells' receptors for testosterone, an androgen, are deaf to the testosterone's instructions, and will thus develop the default external sexual characteristics of a female.—Ariel Levy, The New Yorker, 30 Nov. 2009>—called also testicular feminization, testicular feminization syndrome
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