1 a: an act or instance of resisting:oppositionb: a means of resisting 2: the power or capacity to resist: as a: the inherent ability of an organism to resist harmful influences (as disease, toxic agents, or infection) b: the capacity of a species or strain of microorganism to survive exposure to a toxic agent (as a drug) formerly effective against it 3: an opposing or retarding force 4 a: the opposition offered by a body or substance to the passage through it of a steady electric current b: a source of resistance 5: a psychological defense mechanism wherein a patient rejects, denies, or otherwise opposes the therapeutic efforts of a psychotherapist 6often capitalized: an underground organization of a conquered or nearly conquered country engaging in sabotage and secret operations against occupation forces and collaborators