1 a: the act or process or an instance of reacting b: resistance or opposition to a force, influence, or movement; especially: tendency toward a former and usually outmoded political or social order or policy 2: a response to some treatment, situation, or stimulus <her stunned reaction to the news>; also: such a response expressed verbally <critical reaction to the play> 3: bodily response to or activity aroused by a stimulus: a: an action induced by vital resistance to another action; especially: the response of tissues to a foreign substance (as an antigen or infective agent) b: depression or exhaustion due to excessive exertion or stimulation c: heightened activity and overaction succeeding depression or shock d: a mental or emotional disorder forming an individual's response to his or her life situation 4: the force that a body subjected to the action of a force from another body exerts in the opposite direction 5 a (1): chemical transformation or change : the interaction of chemical entities (2): the state resulting from such a reaction b: a process involving change in atomic nuclei