off-label

adjective

off-la·​bel ˈȯf-ˌlā-bəl How to pronounce off-label (audio)
: of, relating to, or being a drug used to treat a condition for which it has not been officially approved

Examples of off-label in a Sentence

Recent Examples on the Web Navigating insurance coverage for off-label prescriptions can be challenging. Caroline Hopkins, NBC News, 31 Mar. 2024 The group ultimately recommended an off-label use in children, given the large number of kids affected by mpox in the DRC. Gabrielle Emanuel, NPR, 27 Mar. 2024 Among their allegations: Some doctors on the hospital’s cleft team were performing bone grafts on patients who were too young — around age 2 — and using an off-label, controversial bone growth product that many doctors shun. Megan Rose, ProPublica, 6 Mar. 2024 Spironolactone is another blood pressure drug that’s been shown to have anti-androgen effects (which is why it’s commonly prescribed as an off-label treatment for hormonal acne). Krissy Brady, SELF, 5 Mar. 2024 His neurologist placed him on memantine, using it off-label. Judy Stone, Forbes, 28 Feb. 2024 While Xolair could previously be prescribed off-label for food allergies, insurance companies rarely cover off-label uses. Kaitlin Sullivan, NBC News, 25 Feb. 2024 Children’s Health Defense says its legal team works closely with state attorneys general to protect off-label use of ivermectin and hydroxychloroquine to prevent or treat covid; attorneys general in six states have done so. Lauren Weber, Washington Post, 21 Feb. 2024 The American College of Obstetricians and Gynecologists (ACOG) offers clinical guidance based on studies of off-label use of existing treatments, but innovation in this space has been stagnant for nearly two decades. Brittany Barreto, Forbes, 13 Feb. 2024

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'off-label.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1987, in the meaning defined above

Time Traveler
The first known use of off-label was in 1987

Dictionary Entries Near off-label

Cite this Entry

“Off-label.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/off-label. Accessed 19 Apr. 2024.

Medical Definition

off-label

adjective
off-la·​bel ˌȯf-ˌlā-bəl How to pronounce off-label (audio)
: of, relating to, or being an approved drug legally prescribed or a medical device legally used by a physician for a purpose (as the treatment of children or of a certain disease or condition) for which it has not been specifically approved (as by the United States Food and Drug Administration)
the off-label use of oral contraceptives to treat dysmenorrhea
Last Updated: - Updated example sentences
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