lesion

noun

le·​sion ˈlē-zhən How to pronounce lesion (audio)
Synonyms of lesionnext
1
2
: an abnormal change in structure of an organ or part due to injury or disease
especially : one that is circumscribed (see circumscribe sense 1) and well-defined
lesioned adjective

Examples of lesion in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Its early symptoms include lesions around the infection site, fever and fatigue. Emma Gometz, Scientific American, 22 Jan. 2026 Computer vision algorithms trained on over 50,000 clinical data points segment and classify every lesion, assigning risk scores for each. Craig S. Smith, Forbes.com, 21 Jan. 2026 After eight weeks, 75% of participants treated with the Corvus pill, called soquelitinib, achieved at least a 75% improvement in the extent and severity of skin lesions — an efficacy metric known as EASI 75 — compared to 20% of participants offered a placebo, the company said. Adam Feuerstein, STAT, 20 Jan. 2026 The most common problem was persistent lesions in one or more areas of the body. Mary Kekatos, ABC News, 19 Jan. 2026 See All Example Sentences for lesion

Word History

Etymology

Middle English, from Anglo-French, from Latin laesion-, laesio, from laedere to injure

First Known Use

15th century, in the meaning defined at sense 1

Time Traveler
The first known use of lesion was in the 15th century

Browse Nearby Words

Cite this Entry

“Lesion.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lesion. Accessed 28 Jan. 2026.

Kids Definition

lesion

noun
le·​sion ˈlē-zhən How to pronounce lesion (audio)
: a change in the structure of a bodily organ or part due to injury or disease
especially : an injured or diseased spot or area clearly marked off from healthy tissue around it

Medical Definition

lesion

1 of 2 noun
le·​sion ˈlē-zhən How to pronounce lesion (audio)
: an abnormal change in structure of an organ or part due to injury or disease
especially : one that is circumscribed and well defined
lesioned adjective

lesion

2 of 2 transitive verb
: to produce lesions in (as an animal's brain)

Legal Definition

lesion

noun
le·​sion ˈlē-zhən How to pronounce lesion (audio)
in the civil law of Louisiana : loss from failure to receive a threshold amount or value (as one-half market value) for immovable property conveyed or transferred by a commutative contract (as a sale or exchange)

called also lesion beyond moiety

compare unjust enrichment
Etymology

Anglo-French, damage, injury, from Latin laesio, from laedere to injure

More from Merriam-Webster on lesion

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!