Definition of Cushing's syndrome
: an abnormal bodily condition that is caused by excess corticosteroids and especially cortisol usually from adrenal or pituitary hyperfunction and is characterized especially by obesity, hypertension, muscular weakness, and easy bruising
First Known Use of cushing's syndrome
Medical Definition of Cushing's syndrome
: an abnormal condition caused by excess levels of corticosteroids and especially cortisol in the body due either to hyperfunction of the adrenal gland (as from adrenal adenoma or hypersecretion of ACTH by the pituitary gland) or to prolonged use of corticosteroid medications (as prednisone) and that is characterized by a variety of signs and symptoms including a change in appearance marked by moon face with plethora and truncal obesity, easy bruising, fatigue, muscle weakness, and hypertension—called also adrenogenital syndrome; compare cushing's disease, hyperadrenocorticism
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