RNA interference

noun

: a posttranscriptional genetic mechanism of eukaryotes that suppresses gene expression and in which double-stranded RNA cleaved into small fragments initiates the degradation of a complementary messenger RNA sequence
also : a technique (such as the introduction of double-stranded RNA into an organism) that artificially induces RNA interference and is used for studying or regulating gene expression

Examples of RNA interference in a Sentence

Recent Examples on the Web This investigational RNA interference therapeutic agent inhibits the production of the protein that causes hypertension, or high blood pressure. Rachel Murphy, Verywell Health, 8 Aug. 2023 Like five other medicines developed by Alnylam and approved by the Food and Drug Administration since 2018, its hypertension drug relies on RNA interference, or RNAi, to fight disease. Jonathan Saltzman, BostonGlobe.com, 24 July 2023 Since 2018, Alnylam has persuaded the Food and Drug Administration to approve five drugs that rely on RNA interference, a Nobel Prize-winning approach to mute disease-causing genes. Jonathan Saltzman, BostonGlobe.com, 26 Apr. 2023 Dicerna was developing medicines that rely on RNA interference, a Nobel Prize-winning technology that turns off disease-causing genes. Jonathan Saltzman, BostonGlobe.com, 1 Sep. 2022 Alnylam is a pioneer in a drug technology called RNA interference, or RNAi, that silences genes that play a role in disease. Joseph Walker, WSJ, 3 Aug. 2022 The story of Alnylam and RNA interference has been pretty well told under your watch. Adam Feuerstein, STAT, 10 Nov. 2021 The discovery of this process—called RNA interference (RNAi)—earned two scientists the 2006 Nobel Prize in Physiology or Medicine. (old) Matt Reynolds, Wired, 8 Nov. 2021 In agricultural biotechnology and in some animal health areas, my company TechAccel is using a similar approach through RNA interference (RNAi) to create safe and insect specific biopesticides, vaccines for diseases in animal health, and other applications. Michael Helmstetter, Forbes, 6 July 2021

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'RNA interference.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1998, in the meaning defined above

Time Traveler
The first known use of RNA interference was in 1998

Dictionary Entries Near RNA interference

Cite this Entry

“RNA interference.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/RNA%20interference. Accessed 18 Apr. 2024.

Medical Definition

RNA interference

noun
: a posttranscriptional genetic mechanism of various eukaryotes (as plants, fungi, nematodes, and mammals) which suppresses gene expression and in which double-stranded RNA cleaved into small fragments initiates the degradation of a complementary messenger RNA sequence
also : a technique (as the introduction of double-stranded RNA into an organism) that artificially induces RNA interference and is used for studying or regulating gene expression
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