allogeneic

adjective

al·​lo·​ge·​ne·​ic ˌa-lō-jə-ˈnē-ik 

variants or less commonly allogenic

ˌa-lō-ˈje-nik 

1

usually allogeneic : involving, derived from, or being individuals of the same species that are sufficiently unlike genetically to interact antigenically

allogeneic stem cells

allogeneic marrow transplantation

compare syngeneic

2

allogenic : caused by the action or influence of abiotic environmental factors

… allogenic (disturbance) processes, such as flooding and sediment deposition patterns, in addition to wind events.

—Brian Lockhart et al.

Examples of allogeneic in a Sentence

Recent Examples on the Web

The second risk for donor-derived, allogeneic therapies is tissue rejection; this occurs when the body treats the new cells as a foreign threat. —William A. Haseltine, Forbes, 14 Feb. 2024

This is an adverse reaction to an allogeneic transplant. —Sarah Fielding, Health, 9 Mar. 2023

The second type, allogeneic hematopoietic stem cell transplantation (HSCT), is more common and involves finding a donation from another person. —Emilie Le Beau Lucchesi, Discover Magazine, 17 Feb. 2023

The advent of allogeneic approaches to CAR T therapy is on the rise as new techniques are developed to further translate the potential of CAR T in the clinic. —Demaris Mills, Forbes, 10 Aug. 2022

Though more research is needed, this serves as an early proof of concept outlining some of the potential advantages of an allogeneic approach over autologous CAR T-cells. —Demaris Mills, Forbes, 10 Aug. 2022

Autologous and allogeneic therapy are the future of drug development. —John Cumbers, Forbes, 25 Jan. 2022

The rest get allogeneic transplants, where donors can include siblings or unrelated donors determined to be a match. —Ron Winslow, WSJ, 28 May 2018

The company is taking over Pfizer Inc.’s collaboration and license agreement with Cellectis to develop a series of allogeneic CAR-T therapies, including UCART19, a blood cancer drug in Phase I clinical trials. —Brian Gormley, WSJ, 3 Apr. 2018

Word History

Etymology

alteration of allogenic, from allo- + -genic

Note: The word allogenic as a term in genetics was introduced by the British immunologist Peter A. Gorer (1907-61) in the article "Transplantese," Annals of the New York Academy of Science, vol. 87, no. 1 (May, 1960), pp. 604-606. In a subsequent article (P. A. Gorer, et al., "Proposed revisions of 'Transplantese'," Nature, vol. 189, no. 4769 (March 25, 1961), pp. 1024-25), the suggestion is made that allogenic be changed to allogeneic to avoid confusion with allergenic. The later article also introduces syngeneic as a synonym for earlier isogenic.

First Known Use

1929, in the meaning defined at sense 2

Medical Definition

allogeneic

adjective

al·​lo·​ge·​ne·​ic ˌal-ō-jə-ˈnē-ik 

variants also allogenic

-ˈjen-ik 

: involving, derived from, or being individuals of the same species that are sufficiently unlike genetically to interact antigenically

allogeneic skin grafts

compare syngeneic, xenogeneic