Creutzfeldt-Jakob disease

noun

Creutz·​feldt-Ja·​kob disease ˈkrȯits-ˌfelt-ˈyä-(ˌ)kōb- 

variants or less commonly Creutzfeld-Jakob disease

: a rare progressive fatal encephalopathy caused by a prion and marked by development of porous brain tissue, premature dementia in middle age, and gradual loss of muscular coordination

Examples of Creutzfeldt-Jakob disease in a Sentence

Recent Examples on the Web

Some of the 1,848 patients who received cadaver hormone developed Creutzfeldt-Jakob disease (CJD), a rare but always fatal brain disorder caused by a type of prion known as PrP-amyloid plaques. —Erin Prater, Fortune Well, 1 Feb. 2024

The treatment approach was discontinued after cases of a rare brain disorder called Creutzfeldt-Jakob disease were found to be associated with the administration of contaminated human growth hormone from cadavers. —Jacqueline Howard, CNN, 29 Jan. 2024

Doctors suspected Mike could have suffered from Creutzfeldt-Jakob disease (CJD), a rare and fatal neurodegenerative disorder in which brain proteins are abnormally folded. —Timothy Bella, Washington Post, 9 Nov. 2023

Odd Autopsy Three years ago, Collinge and colleagues found a disturbing collection of clumps in the brains of eight patients who had died of Creutzfeldt-Jakob disease or CJD, a fatal brain disorder. —Roni Dengler, Discover Magazine, 13 Dec. 2018

Since his wife Jody died of a rare brain disease (Creutzfeldt-Jakob disease) in 2018, the coach has put even more time into his volunteer work. —Ben Thomas | [e-mail], al, 7 July 2023

Other conditions linked to dementia include Huntington's disease, Parkinson's disease and Creutzfeldt-Jakob disease, which is part of a group of rare fatal brain disorders known as prion diseases. —Ken Alltucker, USA TODAY, 30 May 2023

Examples include mad cow disease, scrapie, Kuru, and Creutzfeldt-Jakob disease. —William A. Haseltine, Forbes, 9 June 2022

However, the Alzheimer’s Association notes several other conditions that can cause dementia, including Creutzfeldt-Jakob disease, Huntington’s disease, normal pressure hydrocephalus, posterior cortical atrophy, Parkinson’s disease, and Korsakoff syndrome. —Claire Bugos, Verywell Health, 18 Feb. 2023

Word History

Etymology

Hans G. Creutzfeldt †1964 German psychiatrist and Alfons M. Jakob †1931 German psychiatrist

First Known Use

1963, in the meaning defined above

Medical Definition

Creutzfeldt-Jakob disease

noun

Creutz·​feldt-Ja·​kob disease

variants also Creutzfeld-Jakob disease

ˌkrȯits-ˌfelt-ˌyä-(ˌ)kōb- 

: a rare progressive fatal prion disease marked by the development of porous brain tissue, premature dementia in middle age, and gradual loss of muscular coordination

—abbreviation CJD

called also Jakob-Creutzfeldt disease

see variant creutzfeldt-jakob disease